Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry

The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method which MIP synthesized on surface paper, producing chemically selective with molecular recognition sites target analyte. analyte extracted by substrate, posteriorly used conventional PSI-MS analysis. As one most widely drugs abuse world, it was selected to be studied synthetic method. Methamphetamine detected at higher ion signals compared other different drugs, such as lysergic acid diethylamide (LSD) and cocaine, suggesting that chemical affinity methamphetamine. In experiments validate method, linear calibration curve achieved R-squared (R2) > 0.99. Limit detection (LOD) limit quantification (LOQ) were determined 0.8 2.8 µg L-1, respectively. Precision (relative standard deviation) accuracy error) less than 10%, recoveries close 100%. matrix effect below 10%. These data demonstrate possibility using an analytical tool specific/selective analysis forensic sciences.